Jason In setups - playback engine - hardware buffer . You can reduce the buffer to 128 or 256 which should reduce latency to an acceptable and on some instruments, inaudible level. This is a must fro tracking. If you don't mind bypassing all your inserts and aux tracks, you can also set the system to Low Latency Monitoring ( un less you are using an Mbox) which gives you the absolute minimum latency at the expense of monitoring reverb or amplitube etc. If you are using software instruments, LLM is not an option. During mixing, latency is not abn issue so if you get repeated Buffer Overrun errors, raise the hardware buffer to 1024. If you have very processer intensive plugins, they will introduce latency that cannot be reduced except by nudging those tracks forward to compensate. If you use an external mixer and monitor thru the mixer, latency is not an issue except for software instruments. But anything oplugged thru the mixee will sound direct.