I had problems with the mbox2 mini. Incorrect latency reporting, high pitch noise in background (not present with any other combination of our gear that we tried), unbalanced line input and outputs, unstable drivers and or USB instability... I love my delta-66, and I expected that the mbox would work with my other software as well as the delta does. Now I wouldn't touch one with a barge pole. Did i mention the normal windows driver support for them is hopeless? No real directsound drivers, only MME, and they don't work well anyway. Sigh. Would be a great little interface if it worked properly. I don't know if any of this applies to the non-mini mboxes as I haven't used them. Besides, If I was going to spending that much money, I'd probably go with RME, Lynx or MOTU instead.