I'm having a similar issue with panning. I'm on a Macbook Pro, using an Onyx Blackjack. I've tried some of the things in this thread. The master track is set to center and 100% width. In Garageband, I set my inputs and outputs separately, and when I set the outputs to the default system outputs, it pans just fine. But in Reaper, you have to use the same device for both inputs and outputs, oddly enough, so I can't pan while recording. However, after I record something, If I listen to it through the computer audio outputs, it pans just fine. Any ideas?